Hmsay | thomasm | Activity https://hmsay.com/members/thomasm/activity/ Activity feed for thomasm. Mon, 21 Sep 2026 16:06:24 +0000 https://buddypress.org/?v= en-US 30 hourly 2 d008395724cb71a611c8eeee765131cf Ebola haemorrhagic fever is a syndrome that can lead to death within a few days of the onset of symptoms. It directly affects the immune system and the vascular bed, resulting in an extremely high mortality rate. The Ebola virus (EBOV) belongs to the Filoviridae family within the order Mononegavirales. The Filoviridae family comprises three genera: Ebola virus, Marburg virus and Cueva virus. The Ebola virus genus is further subdivided into five species, each represented by a unique virus: Taï Forest Ebola virus (TAFV), Reston Ebola virus (RESTV), Sudan Ebola virus (SUDV), Bundibugyo Ebola virus (BDBV), and Zaire Ebola virus (EBOV). EBOV is the most prominent of these. BDBV is considered a less virulent Ebola virus due to its lower case fatality rate in human and animal outbreaks (25% to 51%). In contrast, the case fatality rate following Ebola virus infection in non-human primates is almost always fatal. While in-depth transcriptomic analyses have been conducted on samples from human patients and non-human primates infected with the Ebola virus, no such studies have been conducted on the Bundibugyo virus. The clinical manifestations of Ebola virus infection in humans and non-human primates (NHPs) are similar and include viremia, cytokine storm and consumptive coagulopathy, which can lead to septic shock and multiple organ failure. The virus initially replicates in monocytes and dendritic cells before spreading to hepatocytes, endothelial cells and epithelial cells. In May 2026, the World Health Organization (WHO) received a report of a highly fatal Bondibougio virus outbreak in Mongbwalu Health Zone, Ituri Province, Democratic Republic of the Congo (DRC), which resulted in deaths among healthcare workers. The Bondibougio virus forms filamentous viral particles and is closely related to the Zaire Ebola virus. It is one of several viruses that can cause Ebola in humans, presenting as viral haemorrhagic fever. Unlike Ebola virus disease, there are currently no approved vaccines or specific treatments for the Bondibougio virus, but early supportive care can save lives. This outbreak has once again drawn global attention to Ebola, highlighting the urgent need to develop effective diagnostic and preventive products. Recognizing the urgent need for more effective tools to combat BDBV, Creative Diagnostics is monitoring the current outbreak closely and has swiftly introduced a range of products to support BDBV infection and vaccine research, including antibodies, ELISA kits, RT-PCR kits, and nucleic acid standard references. Creative Diagnostics will continue to provide research solutions to assist scientists, public health researchers and biotechnology organizations in deeper understanding of this emerging pathogen. To learn more about Creative Diagnostics’ research products and outbreak response reagents, please visit https://www.creative-diagnostics.com/bundibugyo-virus-bdbv-outbreak-response.htm https://hmsay.com/activity/p/31617/ Mon, 14 Sep 2026 05:26:17 +0000

Ebola haemorrhagic fever is a syndrome that can lead to death within a few days of the onset of symptoms. It directly affects the immune system and the vascular bed, resulting in an extremely high mortality rate. The Ebola virus (EBOV) belongs to the Filoviridae family within the order Mononegavirales. The Filoviridae family comprises three…Read More

]]> 0 3087979dc37133ac44b99ddadfcf9e9a https://www.creative-diagnostics.com/hantavirus.htm Hantaviruses are emerging zoonotic pathogens that belong to the Bunyaviridae family. The US Centers for Disease Control and Prevention (CDC) classifies them as Category A pathogens. They pose a serious threat to human health as their infection can lead to haemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS), both of which are highly fatal. These pathogens are transmitted to humans via aerosols containing the excreta of infected rodent hosts. Hantaviruses possess a tripartite negative-strand RNA genome. The three genomic RNA segments (S, M and L) encode the nucleocapsid protein (N), a precursor glycoprotein (which forms two envelope glycoproteins, Gn and Gc upon processing), and the viral RNA-dependent RNA polymerase (RdRp). The N protein is the virus's primary structural component and its main function is to protect and encapsulate the three genomic RNA strands to form three viral ribonucleocapsids. Recent studies suggest that the N protein acts in concert with RdRp to play a crucial role in the transcription and replication of the viral genome. Furthermore, the N protein preferentially promotes the translation of viral mRNA within the cell. There are currently no antiviral therapies or vaccines available to treat hantavirus-associated diseases. A deeper understanding of the molecular mechanisms underlying the hantavirus life cycle could help to identify targets for antiviral therapy and design potential antiviral drugs to treat HFRS and HCPS. In view of the alarming case-fatality rate of hantavirus diseases, the development of an effective hantavirus vaccine is imperative. As the early clinical manifestations of hantavirus infection are often similar to common seasonal respiratory or influenza-like illnesses, there is an urgent need for highly sensitive, reliable and standardized laboratory diagnostic tools to enable early differential diagnosis and accurate target validation. To address these research challenges, Creative Diagnostics offers a range of hantavirus research reagents and products covering multiple strains, including Hantavirus, Puumala virus (PUUV), Seoul virus (SEOV) and Sin Nombre virus (SNV). Creative Diagnostics' new product line includes: 1) Recombinant hantavirus antigens for assay development; 2) high-affinity monoclonal and polyclonal antibodies, which have been validated for capture and detection uses across multiple platforms, including Western blot, flow cytometry, immunohistochemistry and surface plasmon resonance; 3) supporting reagents for ELISA and rapid immunoassay research. For detailed product specifications, volume pricing, or to browse the complete list of available viral solutions, please visit the official product portal at https://www.creative-diagnostics.com/hantavirus.htm. About Creative Diagnostics Creative Diagnostics is a leading manufacturer and supplier of antibodies, viral antigens, innovative diagnostic components, and critical assay reagents. In addition to providing contract R&D and biologic manufacturing services for diagnostic manufacturers along with GMP biologics manufacturing for the biopharmaceutical market, the company aims to continue to act as a trusted source for all researchers' assay development and manufacturing needs. https://hmsay.com/activity/p/19414/ Mon, 20 Jul 2026 05:17:02 +0000

https://www.creative-diagnostics.com/hantavirus.htm

Hantaviruses are emerging zoonotic pathogens that belong to the Bunyaviridae family. The US Centers for Disease Control and Prevention (CDC) classifies them as Category A pathogens. They pose a serious threat to human health as their infection can lead to haemorrhagic fever with renal syndrome…Read More

]]> 0 0d3b848c5c4ec7c7706183e749aafa25 For more information regarding the SpeX™ Earthworm Microsomes or to request a quote, please visit https://qbd.creative-diagnostics.com/spex-earthworm-microsomes.html. https://hmsay.com/activity/p/6983/ Mon, 20 Apr 2026 05:46:49 +0000

For more information regarding the SpeX™ Earthworm Microsomes or to request a quote, please visit https://qbd.creative-diagnostics.com/spex-earthworm-microsomes.html.

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